Target Oriented Synthesis

Nowadays, synthetic chemists have the tools available to make almost every molecule that can be made.  Nonetheless, making desired molecules efficiently, at low cost and with minimal waste is hugely challenging.  Target oriented synthesis looks to build target molecules using a systematic approach whereby smaller molecules are brought together to make more valuable compounds.  The approach is of huge value in modern drug discovery, for example, where millions of molecules are screened each year for their ability to bind to a target protein or beneficially influence a biological pathway.  Through target oriented synthesis it is possible to make complex molecules found in Nature as well as new molecules with potential for impact.

Key Abstracts

Macrocylic bisbibenzyl natural products and their chemical synthesis

DC Harrowven, SL Kostiuk, Nat. Prod. Rep. 2012, 2, 223-242

A Corey-Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bisbibenzyl Analogue

FA Almalki, DC Harrowven, Eur. J. Org. Chem. 2016, 5738–5746

An Approach to the Core of Lactonamycin

PJ Parsons, DR Jones, LJ Walsh, LAT Allen, A Onwubiko, L Preece, J Board, JP White, Org. Lett., 2017, 19, 2533-2535

Total Synthesis of (-)-Colombiasin A and (-)-Elisapterosin B

DC Harrowven, DD Pascoe, D Demurtas, HO Bourne, Angew. Chem.,  2005, 117, 1247-1248

 

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