High Pressure Synthesis

In organic synthesis, high pressures are a potent technique in the green chemistry toolbox, acting like a “physical catalysis” to accelerate sluggish reactions and chemical transformations that are otherwise impossible to achieve. Indeed, high pressure allows many chemical reactions to be performed in the absence of toxic and/or expensive chemical catalysts by squeezing them together until they are forced to react. From an energetic point of view, they constitute a sober, clean and green activation method, requiring energy only to perform the compression step at the onset of the reaction.

The LabFact team has four high pressure reactors that allow us to perform organic experiments at pressures up to 16 kbars.

En chimie organique, la synth√®se sous haute pression est une technique puissante, utilis√©e comme une “catalyse physique” pour acc√©l√©rer les r√©actions lentes et les transformations chimiques qui seraient autrement impossibles √† r√©aliser. Cette m√©thode permet d’effectuer de nombreuses r√©actions chimiques en l’absence de catalyseurs chimiques toxiques et/ou on√©reux en comprimant les r√©actifs jusqu’√† ce qu’ils soient contraints de r√©agir. D’un point de vue √©nerg√©tique, cette technique repr√©sente une m√©thode d’activation propre et verte, ne n√©cessitant de l’√©nergie que pour r√©aliser l’√©tape de compression, au d√©but de la r√©action.

L’√©quipe LabFact dispose de quatre r√©acteurs √† haute pression permettant de r√©aliser des exp√©riences √† des pressions allant jusqu’√† 16 kbars.

Associated Companies:


Members Involved:

Key Publications:

  • High Pressure Elicits Unexpected Transformations of Plain Nitroaromatics with 4-(Cyclohex-1-en-1-yl)morpholine, S.¬†Diab, L. No√ęl-Duchesneau, M. Sanselme, Y. Kondo, M. De Paolis,¬† I. Chataigner,¬†¬†Eur. J. Org. Chem. 2018, 2048-2052.
  • Benefits of a Dual¬†Chemical and Physical Activation: direct aza-Michael Addition of Anilines Promoted by Solvent Effect under Ultra-High Pressure, A.¬†Fedotova, B. Crousse, I, Chataigner, J. Maddaluno, A. Rulev, J. Legros,¬†J. Org. Chem. 2015, 80, 10375-10379.
  • Multicomponent Domino [4+2]/[3+2] Cycloadditions of Nitroaromatics: an Efficient Synthesis of Fused Nitrogenated Tetracycles, I,¬†Chataigner, S. R. Piettre,¬†Org. Lett. 2007, 9, 4159-4162.