Cycloaddition reactions build ring-containing molecules by simultaneously creating two bonds between reacting molecules. Usually, two molecules with π-bonding combine to form a new cyclic molecule with reduced π-bonding. The most common cycloaddition reaction is the Diels-Alder reaction where a conjugated diene (2 π-bonds) reacts with an alkene (1 π-bond) to form a cyclohexene derivative (1 π-bond). Used appropriately, they provide a rapid means of generating molecular complexity in a controlled and predictable manner. For this reason, they are widely used in industry for the synthesis of medicines and agrochemicals.
Total Synthesis of (-)-Colombiasin A and (-)-Elisapterosin B
A Thermally Induced Hydride Transfer from an Amine to an Allene Triggers an Annulation Reaction, Giving Dihydrofuropyridinones