Cascade / Domino Reactions

A domino reaction is defined by one of the leaders in the field, Lutz Tietze, as a “transformation of two or more bond-forming reactions under identical reaction conditions, in which the latter transformations take place at the functionalities obtained in the former bond forming”.

This economical and efficient approach allows the use of transient and unstable species to build complex molecules within a single series of reactions.

Key Abstracts

Thermally Induced Cyclobutenone Rearrangements and Domino Reactions

David C. Harrowven*, David D. Pascoe and Ian L. Guy, Angew. Chem. Int. Ed. 2007, 46, 425–428

Domino Ring Expansion: Regioselective Access to 9‐Membered Lactones with a Fused Indole Unit from 2‐Nitrophenyl‐1,3‐cyclohexanediones

Nucleophilic Addition-Initiated Ring Expansion and Selectivity in Anionic Fragmentation

David Reyes Loya and Michaël De Paolis* Chem. Eur. J. 2018, 24












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