Synthetic chemists look to take molecules that are cheap and easy to source and transform them into more valuable molecules. To do this they use chemical reactions to build molecular complexity. However, as most chemical reactions make or break a very limited number of chemical bonds, it is often necessary to build-up molecular complexity gradually by sequencing many reactions one-after-another. Daisy chain reactions represent a special case as the sequencing of chemical reactions is performed without the isolation of intermediate products. This can speed up the manufacturing processes greatly by reduce the time needed to make a product. However, the development of daisy chain reactions is challenging as inefficiencies in any of the individual reactions will compromise the sequence as a whole.
The LabFact team have a number of active projects in this area, most of which are looking to use flow chemistry techniques to sequence reagentless (light, heat, pressure, microwaves) chemical reactions for the rapid and controlled generation of molecular complexity.
- A Thermally Induced Hydride Transfer from an Amine to an Allene Triggers an Annulation Reaction giving Dihydrofuropyridinones. W. Sun, D. C. Wilson, M. E. Light, D. C. Harrowven, Org. Lett. 2018, 20, 4346–4349.