The rationale design of functional molecular scaffolds with predictable and tunable physical, chemical and biological properties is a key activity of LabFact. Our partners have experience in engineering scaffolds for a diverse range of applications, including as chemical probes, modulators of biological activity, building blocks, rule of three fragments, new functional materials and new catalysts, amongst others.
The amyloid architecture provides a scaffold for enzyme-like catalysts
Late Stage C-H Activation of a Privileged Scaffold. Synthesis of a Library of Benzodiazepines
Microwave-Assisted Synthesis of 3-Aminobenzo[b]thiophene Scaffolds for the Preparation of Kinase Inhibitors
A Poised Fragment Library Enables Rapid Synthetic Expansion Yielding the First Reported Inhibitors of PHIP(2), an Atypical Bromodomain