Scaffold Design

The rationale design of functional molecular scaffolds with predictable and tunable physical, chemical and biological properties is a key activity of LabFact. Our partners have experience in engineering scaffolds for a diverse range of applications, including as chemical probes, modulators of biological activity, building blocks, rule of three fragments, new functional materials and new catalysts, amongst others.

Key Abstracts

The amyloid architecture provides a scaffold for enzyme-like catalysts

 Z. S. Al-Garawi, B. A. McIntosh, D. Neill-Hall, A. A. Hatimy, S. M. Sweet, M. C. Bagley, L. C. Serpell, Nanoscale, 2017, 9, 10773-10783

Late Stage C-H Activation of a Privileged Scaffold. Synthesis of a Library of Benzodiazepines

Khan, R. Felix, P. D. Kemmitt, S. J. Coles, I. J. Day, G. J. Tizzard, J. Spencer, Adv. Synth. Catal., 2016, 358, 98-109

Microwave-Assisted Synthesis of 3-Aminobenzo[b]thiophene Scaffolds for the Preparation of Kinase Inhibitors

M. C. Bagley, J. E. Dwyer, M. D. B. Molina, A. Rand, H. L. Rand, N. C. O. Tomkinson, Biomol. Chem. 2015, 13, 6814-6824

A Poised Fragment Library Enables Rapid Synthetic Expansion Yielding the First Reported Inhibitors of PHIP(2), an Atypical Bromodomain

Cox, B., Krojer, T.; Collins, P.; Monteiro, O.; Talon, R.; Bradley, A.; Fedorov, O.; Amin, J.; Marsden, B. D.; Spencer, J.;  Von Delft, F.; Brennan, P. E. Chem. Sci. 2016, 7, 2322-2330

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