Organocatalysis describes the acceleration of chemical reactions through the addition of a small amount of an organic catalyst. The catalyst operates through the transient formation of bonds to the starting material making it responsive to chemical reactions. Such processes provide powerful tools in the construction of complex and valuable molecules.
The Labfact partners have developed projects in this field, with a special focus on Lewis bases and ammonium based phase transfer catalysts.
L’organocatalyse est une approche de synthĂšse moderne qui repose sur l’accĂ©lĂ©ration de rĂ©actions chimiques, sous lâinfluence d’une quantitĂ© sous-stĆchiomĂ©trique d’une molĂ©cule organique.  Le catalyseur assure lâactivation du substrat, par le biais de la formation transitoire de liaisons, covalentes ou non covalentes. De tels procĂ©dĂ©s constituent des outils puissants dans la construction de molĂ©cules complexes, Ă haute valeur ajoutĂ©e.
Les partenaires du projet Labfact ont dĂ©veloppĂ© des mĂ©thodologies dans ce domaine, avec un accent particulier sur lâutilisation catalytique de bases de Lewis et/ou de sels dâammonium quaternaires (agents de transfert de phase).
Key Abstracts
Unique Reactivity of αâSubstituted ElectronâDeficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts
Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent
SulfinateâOrganocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines
Martzel, J.-F. Lohier, A.-C. Gaumont, J.-F. BriĂšre, S. Perrio, Eur. J. Org. Chem., 2018 5069â5073
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