Heteroatom Chemistry

Many commercially available drugs and agrochemical compounds contain heteroatoms, especially sulfur, phosphorus and fluorine. It can be estimated that up to 50% of drugs contain these heteroatoms and their introduction is not trivial.  Labfact teams have a number of projects on the selective introduction of such heteroatoms by the creation of carbon-heteroatom bonds and from building-blocks.

Key Abstracts

Metal-Free, Visible Light-Photocatalyzed Synthesis of Benzo[b]phosphole Oxides: Synthetic and Mechanistic Investigations

V. Quint, F. Morlet-Savary, J-F. Lohier, J. Lalevée, A-C. Gaumont, S. Lakhdar, J. Am. Chem. Soc2016138, 7436–7441


Sulfinate-organocatalyzed (3+2) annulation of allenyl sulfones with 1,1-dicyano olefins in the presence of a quaternary ammonium phase transfer agent

Martzel, T.; Lohier, J.-F.; Gaumont, A.-C.; Brière, J.-F.; Perrio, S. Adv. Synth. Catal., 2018, 360, 2696–2706




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