Many commercially available drugs and agrochemical compounds contain heteroatoms, especially sulfur, phosphorus and fluorine. It can be estimated that up to 50% of drugs contain these heteroatoms and their introduction is not trivial. Labfact teams have a number of projects on the selective introduction of such heteroatoms by the creation of carbon-heteroatom bonds and from building-blocks.
Metal-Free, Visible Light-Photocatalyzed Synthesis of Benzo[b]phosphole Oxides: Synthetic and Mechanistic Investigations
Sulfinate-organocatalyzed (3+2) annulation of allenyl sulfones with 1,1-dicyano olefins in the presence of a quaternary ammonium phase transfer agent