Photochemical Synthesis

In the context of chemical manufacture, photochemists look to use light rather than a chemical reagent to trigger chemical reactions.  Many chemical reactions can be performed using ultraviolet and visible light, which excites molecules into a reactive state.  Reactions that proceed via an excited state often give access to chemical products that would be difficult and expensive to prepare by other means.  The LabFact team has a number of active projects in this area with expertise in flow photochemistry, photocatalysis and reactor design.

Members Involved:

Key Publications:

  • An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements, D. C. Harrowven,  M. Mohamed, T. P. Goncalves, R. J. Whitby, D. Bolien, H. F. Sneddon, Angew. Chem. Int. Ed. 2012, 51, 4405–4408.
  • Metal-Free, Visible Light-Photocatalyzed Synthesis of Benzo[b]phosphole Oxides: Synthetic and Mechanistic Investigations, V. Quint, F. Morlet-Savary, J-F. Lohier, J. Lalevée, A-C. Gaumont, S. Lakhdar, J. Am. Chem. Soc2016138, 7436–7441.
  • How Do Phosphinates React with Unactivated Alkenes Under Organic Photocatalyzed Conditions? Substrate Scope and Mechanistic Insights. G. Fausti, F. Morlet-Savary, J. Lalevée, A.-C. Gaumont, S. Lakhdar, Chem. Eur. J201723, 2144–2148.