Organocatalysis

Organocatalysis describes the acceleration of chemical reactions through the addition of a small amount of an organic catalyst.  The catalyst operates through the transient formation of bonds to the starting material making it responsive to chemical reactions.  Such processes provide powerful tools in the construction of complex and valuable molecules.

The Labfact partners have developed projects in this field, with a special focus on Lewis bases and ammonium based phase transfer catalysts.

Key Publications:

  • Unique Reactivity of a-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts, T. Martzel, J.-F. Lohier, A.-C. Gaumont, J.-F. Brière, S. Perrio, Synth. Catal., 2017, 359, 96–106.
  • Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent, Martzel, J.-F. Lohier, A.-C. Gaumont, J.-F. Brière, S. Perrio, Adv. Synth. Catal., 2018, 360, 2696–2706.
  • SulfinateOrganocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines, Martzel, J.-F. Lohier, A.-C. Gaumont, J.-F. Brière, S. Perrio, Eur. J. Org. Chem., 2018, in press.

Members Involved: